Hemodynamic and cardiac effects of centrally acting antihypertensive drugs.
نویسندگان
چکیده
منابع مشابه
Hemodynamic and cardiac effects of centrally acting antihypertensive drugs.
The centrally acting alpha-adrenergic receptor agonist compounds have been available for treatment of hypertension for more than 25 years. Through studies of these compounds during this time, new knowledge has been made available not only on their mechanisms of antihypertensive action but also on the role of the adrenergic nervous system in essential hypertension. This discussion primarily revi...
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It has been well established that the antihypertensive drugs clonidine and methyldopa lower blood pressure by acting on postsynaptic alpha 2-adrenergic receptors within cardiovascular control centers of the brain. A number of novel agents designed as lipophilic and highly selective alpha 2-adrenergic stimulants have been synthesized and in general the pharmacological features of these agents re...
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We investigated the acute effects of centrally acting antihypertensive drugs on the microcirculation of pentobarbital-anesthetized spontaneously hypertensive rats (SHR). The effects of the sympatho-inhibitory agents clonidine and rilmenidine, known to activate both alpha2-adrenoceptors and nonadrenergic I1-imidazoline binding sites (I1BS) in the central nervous system, were compared to those of...
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THE critical flicker frequency (cff) may be defined as the fastest rate at which a flickering source of light appears to be flickering as opposed to being steady. It has a number of determinants including the luminance, wave-length, wave-form, and light-dark ratio of the stimulating light, the area, position, and light-adapted state of the retina illuminated, the duration of exposure, and the s...
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Cypermethrin a widely used insecticide of Pyrethroids (type II) group, was administered in mice at two dose levels (1/10 of LD50 i.e. 2.5 mg/kg and 1/5 of LD50 i.e. 5.0 mg/kg) and pharmacodynamic interactions of insecticide were studied with centrally acting drugs viz. pentobarbital sodium, amphetamine, pentylenetetrazole, acepromazine and analgin. Cypermethrin pretreatment potentiated the acti...
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ژورنال
عنوان ژورنال: Hypertension
سال: 1984
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.6.5_pt_2.ii76